No. |
Type |
PDBs |
Chains |
Lengths |
Positions |
H-Bonds |
ASAs |
SSEs |
RMSD1 |
RMSD2 |
Plot |
View |
UniProt |
Alteration in Function |
4301 |
F-Y |
1pxb |
1doc |
A |
A |
200 |
200 |
201 |
201 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.13 |
φ,ψ |
3D |
|
perturbed the hydrogen-bonding interactions |
4302 |
N-E |
1eua |
1wbh |
C |
C |
44 |
44 |
45 |
45 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.17 |
φ,ψ |
3D |
|
affect catalysis |
4303 |
E-L |
4m6x |
4m6y |
A |
B |
245 |
245 |
244 |
244 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.53 |
φ,ψ |
3D |
|
NA |
4304 |
A-M |
236l |
1cu3 |
A |
A |
86 |
86 |
87 |
87 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.35 |
φ,ψ |
3D |
|
NA |
4305 |
C-S |
3n1z |
3n1x |
A |
A |
199 |
199 |
201 |
201 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.58 |
φ,ψ |
3D |
|
NA |
4306 |
N-H |
2gds |
1luv |
D |
A |
29 |
29 |
30 |
30 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.13 |
φ,ψ |
3D |
|
affect stability |
4307 |
K-Y |
3gci |
3jql |
A |
A |
62 |
62 |
64 |
64 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.07 |
φ,ψ |
3D |
|
NA |
4308 |
E-K |
2aqs |
2aqq |
B |
C |
62 |
62 |
94 |
94 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.49 |
φ,ψ |
3D |
|
NA |
4309 |
N-S |
1mm7 |
1lbc |
B |
A |
239 |
239 |
242 |
242 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.29 |
φ,ψ |
3D |
|
affect stability |
4310 |
N-D |
2pym |
2q64 |
A |
B |
87 |
87 |
88 |
88 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.35 |
φ,ψ |
3D |
|
affect enzyme vitality |
4311 |
A-Y |
3zyx |
2xfo |
B |
B |
323 |
323 |
326 |
326 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.10 |
φ,ψ |
3D |
|
affect binding affinity |
4312 |
Q-H |
3cdr |
3f8v |
A |
A |
95 |
95 |
96 |
96 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.29 |
φ,ψ |
3D |
|
NA |
4313 |
W-V |
1a2y |
1g7m |
A |
A |
91 |
91 |
92 |
92 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.28 |
φ,ψ |
3D |
|
affect the affinity for HEL |
4314 |
N-S |
2xh7 |
2xh2 |
B |
C |
38 |
38 |
39 |
39 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
2.77 |
φ,ψ |
3D |
|
affect activity |
4315 |
C-T |
4h4d |
3t0g |
B |
B |
166 |
166 |
167 |
167 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.15 |
φ,ψ |
3D |
|
lead to an alternative substrate conformation |
4316 |
E-F |
1yda |
1ydb |
A |
A |
192 |
192 |
198 |
198 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.21 |
φ,ψ |
3D |
|
NA |
4317 |
A-S |
1rb5 |
1ij3 |
C |
A |
15 |
15 |
16 |
16 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.36 |
φ,ψ |
3D |
|
NA |
4318 |
L-W |
3nmm |
3qjd |
A |
A |
57 |
57 |
58 |
58 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.35 |
φ,ψ |
3D |
|
NA |
4319 |
E-K |
2iif |
2iie |
A |
A |
88 |
88 |
89 |
89 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.19 |
φ,ψ |
3D |
|
affect the conformational switch between open and closed state |
4320 |
E-H |
3mn0 |
4fwz |
A |
A |
28 |
28 |
29 |
29 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.33 |
φ,ψ |
3D |
|
NA |
4321 |
R-G |
1hgh |
1hge |
A |
E |
134 |
134 |
135 |
135 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.27 |
φ,ψ |
3D |
|
|
4322 |
R-L |
3lbm |
1hl2 |
C |
B |
139 |
139 |
142 |
142 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.30 |
φ,ψ |
3D |
|
affect activity and catalysis |
4323 |
D-V |
4nuw |
3nqg |
B |
A |
147 |
147 |
155 |
155 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.49 |
φ,ψ |
3D |
|
affect the value of k(cat) by as much as 400-fold |
4324 |
Q-E |
1hvf |
1hvd |
A |
A |
74 |
74 |
78 |
78 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.08 |
φ,ψ |
3D |
|
lead to a smaller conductance level |
4325 |
L-W |
3lci |
3lcg |
C |
C |
248 |
248 |
251 |
251 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.19 |
φ,ψ |
3D |
|
NA |
4326 |
H-S |
1pvw |
1snn |
B |
A |
145 |
145 |
147 |
147 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.29 |
φ,ψ |
3D |
|
NA |
4327 |
R-H |
1obs |
3rti |
A |
A |
174 |
174 |
180 |
180 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.23 |
φ,ψ |
3D |
|
affect activity |
4328 |
A-W |
3zjh |
3zjp |
A |
A |
55 |
55 |
60 |
60 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.27 |
φ,ψ |
3D |
|
affect ligand recognition and stabilization |
4329 |
I-S |
1ct0 |
1cso |
I |
I |
12 |
12 |
18 |
18 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.39 |
φ,ψ |
3D |
|
NA |
4330 |
A-D |
3eyz |
4ez6 |
A |
D |
301 |
301 |
598 |
598 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.69 |
φ,ψ |
3D |
|
NA |
4331 |
L-M |
2enu |
1v37 |
B |
A |
120 |
120 |
121 |
121 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.44 |
φ,ψ |
3D |
|
NA |
4332 |
A-R |
2zy3 |
2zy5 |
A |
A |
468 |
468 |
487 |
487 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.27 |
φ,ψ |
3D |
|
affect activity |
4333 |
K-P |
1fbq |
1fbu |
B |
B |
42 |
42 |
237 |
237 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.78 |
φ,ψ |
3D |
|
affect stability |
4334 |
R-E |
113l |
217l |
A |
A |
43 |
43 |
44 |
44 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.15 |
φ,ψ |
3D |
|
NA |
4335 |
I-L |
1gbx |
1gbw |
A |
A |
109 |
109 |
110 |
110 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.30 |
φ,ψ |
3D |
|
NA |
4336 |
R-Q |
1pbd |
1cj2 |
A |
A |
33 |
33 |
34 |
34 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.13 |
φ,ψ |
3D |
|
affect the binding of NADPH |
4337 |
D-E |
3ouf |
3tcu |
A |
A |
47 |
47 |
68 |
68 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.84 |
φ,ψ |
3D |
|
affect the stability of the K(+) channel selectivity filter |
4338 |
A-E |
1owg |
1owf |
B |
B |
43 |
43 |
44 |
44 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.12 |
φ,ψ |
3D |
|
affect binding affinities |
4339 |
A-N |
1ouc |
1gfv |
A |
A |
109 |
109 |
110 |
110 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.23 |
φ,ψ |
3D |
|
NA |
4340 |
A-W |
2g8d |
2g89 |
A |
A |
260 |
260 |
261 |
261 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.34 |
φ,ψ |
3D |
|
NA |
4341 |
I-F |
1gb6 |
1gb9 |
A |
A |
73 |
73 |
74 |
74 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.15 |
φ,ψ |
3D |
|
NA |
4342 |
S-V |
2qjy |
2qjp |
I |
I |
126 |
126 |
135 |
135 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.26 |
φ,ψ |
3D |
|
NA |
4343 |
A-S |
3b6t |
3b6w |
A |
C |
170 |
170 |
686 |
686 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.42 |
φ,ψ |
3D |
|
NA |
4344 |
A-K |
3uec |
3uee |
A |
C |
57 |
57 |
62 |
62 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.31 |
φ,ψ |
3D |
|
affect binding affinity |
4345 |
A-D |
1spa |
3qpg |
A |
A |
210 |
210 |
222 |
223 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.29 |
φ,ψ |
3D |
|
affect binding affinity and catalytic efficiency |
4346 |
C-E |
3lx3 |
3lze |
A |
A |
27 |
27 |
37 |
37 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.26 |
φ,ψ |
3D |
|
NA |
4347 |
A-S |
1c0e |
1phr |
A |
A |
15 |
15 |
19 |
19 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.38 |
φ,ψ |
3D |
|
altered kinetic properties |
4348 |
D-S |
1lbc |
1lbb |
C |
A |
238 |
238 |
242 |
242 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.24 |
φ,ψ |
3D |
|
NA |
4349 |
T-V |
1p59 |
1orn |
A |
A |
128 |
128 |
129 |
129 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.28 |
φ,ψ |
3D |
|
NA |
4350 |
Q-K |
1uxh |
1uxi |
B |
A |
163 |
163 |
165 |
165 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.24 |
φ,ψ |
3D |
|
NA |
4351 |
R-K |
3lon |
2oin |
C |
A |
126 |
126 |
155 |
181 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.19 |
φ,ψ |
3D |
|
affect replication capacity |
4352 |
A-V |
3p7f |
3c22 |
D |
A |
82 |
82 |
278 |
278 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.47 |
φ,ψ |
3D |
|
NA |
4353 |
A-D |
4nto |
4nt2 |
C |
A |
53 |
53 |
60 |
60 |
0 |
0 |
0.0 |
0.0 |
|
|
0.19 |
0.24 |
φ,ψ |
3D |
|
affect ceramide-1-phosphate (C1P) levels |
4354 |
N-D |
1z5o |
3o4v |
B |
B |
196 |
196 |
197 |
197 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.14 |
φ,ψ |
3D |
|
affect the conformational changes of the enzyme and the nucleoside substrate |
4355 |
N-D |
2nqk |
1g8l |
A |
A |
52 |
52 |
59 |
59 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.22 |
φ,ψ |
3D |
|
lead to a functional differences |
4356 |
C-H |
3m04 |
1cvd |
A |
A |
114 |
114 |
119 |
119 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.17 |
φ,ψ |
3D |
|
NA |
4357 |
I-V |
3oxv |
3oxx |
A |
B |
63 |
63 |
64 |
64 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.29 |
φ,ψ |
3D |
|
NA |
4358 |
P-S |
2qpu |
1ht6 |
C |
A |
377 |
377 |
378 |
378 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.40 |
φ,ψ |
3D |
|
affect activity |
4359 |
Q-H |
1en4 |
3k9s |
A |
C |
145 |
145 |
146 |
146 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.12 |
φ,ψ |
3D |
|
affect dismutase activity |
4360 |
M-V |
1ovg |
3onv |
B |
B |
63 |
63 |
64 |
64 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.25 |
φ,ψ |
3D |
|
affect enzymatic activity |
4361 |
A-I |
1brk |
1a2p |
A |
C |
93 |
93 |
96 |
96 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.16 |
φ,ψ |
3D |
|
affect stability |
4362 |
A-F |
3a6g |
3a6h |
D |
A |
151 |
151 |
154 |
154 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.69 |
φ,ψ |
3D |
|
NA |
4363 |
L-W |
3lcg |
3lci |
B |
B |
249 |
249 |
251 |
251 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.12 |
φ,ψ |
3D |
|
NA |
4364 |
G-Y |
1gft |
1gbo |
A |
A |
109 |
109 |
110 |
110 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.13 |
φ,ψ |
3D |
|
NA |
4365 |
D-V |
1x12 |
1z8x |
C |
A |
191 |
191 |
192 |
192 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.44 |
φ,ψ |
3D |
|
NA |
4366 |
I-M |
1cu0 |
1l63 |
A |
A |
77 |
77 |
78 |
78 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.31 |
φ,ψ |
3D |
|
affect stability and the rate of folding |
4367 |
A-C |
2f71 |
1g1f |
A |
A |
213 |
213 |
215 |
215 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.30 |
φ,ψ |
3D |
|
affect affinity |
4368 |
R-D |
1sgd |
2nu2 |
I |
I |
12 |
12 |
18 |
18 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.23 |
φ,ψ |
3D |
|
NA |
4369 |
N-D |
1lbb |
1mqd |
A |
A |
238 |
238 |
239 |
242 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.21 |
φ,ψ |
3D |
|
affect stability |
4370 |
R-T |
1bp6 |
1bp0 |
A |
A |
178 |
178 |
179 |
179 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.20 |
φ,ψ |
3D |
|
affect activity |
4371 |
N-P |
1sgn |
2sgp |
I |
I |
12 |
12 |
18 |
18 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.57 |
φ,ψ |
3D |
|
NA |
4372 |
A-N |
1ix8 |
1ix7 |
A |
A |
182 |
182 |
194 |
194 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.44 |
φ,ψ |
3D |
|
the aldimine pK(a) |
4373 |
C-H |
1ux0 |
1ux1 |
A |
C |
52 |
52 |
53 |
53 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.26 |
φ,ψ |
3D |
|
affect activity |
4374 |
S-V |
1s51 |
1s52 |
A |
B |
19 |
19 |
24 |
24 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.38 |
φ,ψ |
3D |
|
NA |
4375 |
E-K |
1tt2 |
1tr5 |
A |
A |
80 |
80 |
92 |
92 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.14 |
φ,ψ |
3D |
|
NA |
4376 |
F-V |
1met |
1odw |
A |
A |
81 |
81 |
82 |
82 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.26 |
φ,ψ |
3D |
|
affect the binding affinity to DMP323 |
4377 |
C-Q |
1h9q |
1cvd |
A |
A |
114 |
114 |
119 |
119 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.18 |
φ,ψ |
3D |
|
NA |
4378 |
W-Y |
4lf3 |
4ers |
B |
H |
51 |
51 |
266 |
266 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.52 |
φ,ψ |
3D |
|
NA |
4379 |
R-K |
3qjs |
1xme |
A |
A |
252 |
252 |
258 |
258 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.29 |
φ,ψ |
3D |
|
NA |
4380 |
C-Q |
1r2z |
3gq4 |
A |
A |
164 |
164 |
166 |
166 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.18 |
φ,ψ |
3D |
|
NA |
4381 |
T-V |
2ats |
1s5t |
B |
B |
43 |
43 |
44 |
44 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.77 |
φ,ψ |
3D |
|
affect activity |
4382 |
A-R |
2igc |
2ou9 |
A |
A |
118 |
118 |
119 |
119 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.12 |
φ,ψ |
3D |
|
NA |
4383 |
N-D |
3g2d |
3g3y |
A |
B |
149 |
149 |
151 |
151 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.16 |
φ,ψ |
3D |
|
affect activity |
4384 |
A-Y |
3mi1 |
3t63 |
M |
O |
146 |
146 |
447 |
447 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.95 |
φ,ψ |
3D |
|
NA |
4385 |
A-I |
2cp4 |
1geb |
A |
A |
242 |
242 |
252 |
252 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.59 |
φ,ψ |
3D |
|
NA |
4386 |
N-D |
3l63 |
2a1n |
A |
B |
241 |
241 |
251 |
251 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
1.39 |
φ,ψ |
3D |
|
affect catalytic activity and proton transfer |
4387 |
R-H |
133l |
2nwd |
A |
X |
114 |
114 |
115 |
115 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.10 |
φ,ψ |
3D |
|
No significant change of enzyme activity |
4388 |
E-W |
3sxt |
3rn1 |
A |
A |
193 |
193 |
199 |
199 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.49 |
φ,ψ |
3D |
|
NA |
4389 |
N-Q |
3sxt |
4o1q |
A |
A |
97 |
97 |
103 |
103 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.15 |
φ,ψ |
3D |
|
affect the rate of spontaneous return of the spectrum in the Soret region |
4390 |
E-V |
4mxl |
4fwz |
A |
A |
67 |
67 |
68 |
68 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.16 |
φ,ψ |
3D |
|
NA |
4391 |
E-I |
1r3j |
3or7 |
C |
C |
49 |
49 |
71 |
71 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.18 |
φ,ψ |
3D |
|
affect stability |
4392 |
N-C |
2h4n |
4jsw |
A |
A |
90 |
90 |
94 |
94 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.56 |
φ,ψ |
3D |
|
NA |
4393 |
A-G |
2z5y |
2z5x |
A |
A |
98 |
98 |
110 |
110 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.93 |
φ,ψ |
3D |
|
affect activity |
4394 |
D-E |
117e |
1e6a |
A |
B |
116 |
116 |
1117 |
117 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.25 |
φ,ψ |
3D |
|
affect catalytic efficiency |
4395 |
D-E |
2jk2 |
2vom |
A |
A |
100 |
100 |
104 |
104 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.40 |
φ,ψ |
3D |
|
affect stability but not activity |
4396 |
N-D |
1snr |
2ppf |
A |
C |
94 |
94 |
98 |
98 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.24 |
φ,ψ |
3D |
|
affect NO bound state |
4397 |
A-E |
1i0v |
1lov |
A |
A |
57 |
57 |
58 |
58 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.22 |
φ,ψ |
3D |
|
NA |
4398 |
A-L |
1cvk |
1l63 |
A |
A |
117 |
117 |
118 |
118 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.27 |
φ,ψ |
3D |
|
have little effect on stability |
4399 |
A-F |
1sfd |
1sf3 |
A |
A |
93 |
93 |
94 |
94 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.40 |
φ,ψ |
3D |
|
NA |
4400 |
Q-E |
3b8d |
1zai |
C |
C |
186 |
186 |
187 |
187 |
0 |
0 |
0.0 |
0.0 |
|
|
0.20 |
0.20 |
φ,ψ |
3D |
|
affect proton transfers and compromise activity |